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̵巹ȿ ¶ ౹ 24 ˸ Ʈ ¶ ó ̱ǰ ǰ Ǹ ǰ Ʈó ǰԻ̱ Ʊ׶ ǰ Ʈ Ǹ ¶ Թ ߱ġ ӽð ԻƮ ĺ ϳ౹ ǰ ǰ Ʊ׶ ۿ Ʊ׶ Ʊ׶ ó Ʊ׶ þ˸ ڹѾ˹ ǰ Ʈۿ ǰ óƮ þ˸Թ ͳ ߱ġ Ź Ŵ þ˸ ¶ Ǹó ˸ ɰ ı ǰ Ʈ ¶ Ǹ ó ǰڹ ó޴¹ Ի̱ ó޴¹ ͳ Ǹó ī׶ þ˸ Ʈ ǰ̱Ʊ׶ ȿ ǰ ԻƮ GHB Ǹ ó ȿ GHB ı ȿ ǸóƮ 伺Ȯó ¶ GHB ó Ʊ׶ Ĵ° ɰ Ǹó Ʈ Ʊ׶ ó Ǹó Իεī׶ ۿ GHB Ծ౹ ͳ Ʊ׶ ǸóƮ ͳ ó ౹Ǹ ˸ ¶ Ǹ ɹ Ÿٶ 5mg ī׶ ͳ Ʈ Թ ¶ Ǹ عٶϹ Ź ǰ̱Ʊ׶ Թ ͳ Ʈ ˸ Ⱦƿ Ʈ20mg óƮ þ˸ Ʈ ͳ Թ ǰ弽 ԻƮ ͳ ɰ ó ̱þ˸ ׸ Ʊ׶ þ˸ ǰǸ ǰī׶ ȿ ڹбݾ þ˸ ǰ ǸŻƮ ͳ Ǹó ī׶ʸ ڽȿ Ʈݾ ɰǰ ¶ GHB ó н ǰڹ ó ¶ ߱ġ Ʊ׶Ĵ° Ʊ׶ ʸ ī׶ ȿ ¶ ߱ġ ó GHB ϴ° Ʊ׶ Ϲ þ˸ ǰ ŻƮ þ˸ Ź ͳ ɰ ī׶ Ʈǰ ͳ ɰǸ Ʈ ͳ GHB ó þ˸ ͳ þ˸Ǹ þ˸ ó ߱ġ20mg ˴ϴ ǰԻ̱Ʊ׶ ౹ þ˸ vs Ʊ׶ Ʊ׶󱸸Ź Ǹó Ʈ ǰԻ̱þ˸ Թ GHB ۿ ͳ GHB Ǹó ˸ Ʈ ¶ Ǹó ߱ġϴ°



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ش޶ ϴ ׷ . ΰ ׵ ϸ ϴٰ Ͼ̾. մϱ?վ Ÿ ð £ ݻ ׷ ؼƴϸδ. ü ڰ Ͽȣ ߱ ٵ
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 ƹ ־. ʾҴ ̾. üǹٸ ڸϴ. ׸ üƳ. Ȳ ٰ ̰Թ̰ ڿ ؼ Դ¸ֶ Ӹ Ư Ҹ
ٺ ø Ǹ. ϸ 繫 ȭ å鼭 . ǰ ſ ΰž? 븮 °. ù ֽ ɱ? ¸ ɱ? ¼ ־. ϴ ¾. Ű罬 ƴ üġ? ٸ ̶ ִ
߾. ܹ ູ ϰ԰ Ȧ¦ Ǽ ̷ ȸȭ ȸ' ڴȭ ߴ. ׳ ϴ ʴ °ǵ. ٽ̰Ŷ ׸ ڽ
ȣ Ǵϱ. ¦ ̾. ϼ. 踦 Ҵµ鿴.ã ٸ ڳװ븩 ϰ ׳Ǹ ٵ. . 鼭. ̴. ι̶ ϴ ȿ ǥ ׾߱ ġ ġ ȿ ĿPDE5 , ĵ ׾ ȭп ܡ



߱ ġ Ʊ׶. Ϻ ڷƱ׶ þ˸ ߱ ġ ĵ ׾ġ ȿ ִٴ Դ.ǥ ׾ ܵ 𿡽׶5(PDE5) 迭 ߱ ġ ġ ȿ ũٴ ̴.27 ̱ ȸ(AAAS) Ʈ ũƮ(EurekAlert) ϴ Ǵ ȭ ܰ ڻ ǥߴ.
þ˸
PDE5 迭 ߱ ġ ĵ ̼ȯ Ȱ , ׾ ȭп ϴ Ÿ. ̼ȯ̶ ѷΰ ִ , 忡 ߿ ϴ Ƽ(CAF) ȴ. ̼ȯ 翡 Ҹ ϸ þ˸ ı
ȣ , ׾ ȭп ġᰡ ȿ ŵ ϰ Ѵ. Ư CAF ̼ȯ ϴ ߿ ϳ ˷ ִ. ־ ϴ ȿ PDE5 ĵ 翡 ġ ٴ ߰ߴ. Ư ̼ȯ ο ִ CAF PDE5 ȿҰ , þ˸
ȿ ĵ ִ Ÿ.̸ Ȯϱ ĵ ̼ȯ ä CAF PDE5 ô. , PDE5 CAF Ȱ , CAF Ƽ ٲ. ̾ 8 ĵ ȯ 翡 1þ˸ ౹Ǹ
5 (biopsy) ä ϼ Ű ΰ ǥ ׾ Բ PDE5 ߴ.׷ ׾ ġῡ Ÿ ʾҴ ȯ 12 ΰ 9 ǥ ׾ Ÿ. ׾ ġῡ ̴ ĵ 㿡 ̽ þ˸ ¶
ǥ ׾ ܵ Ǵ PDE5 Բ ߴ. , ǥ ׾ PDE5 Բ ǥ ׾ ũ پ.̹ ̼ ÿ ĵ ġ 40 ݹۿ ٸ鼭 ó ׾ ϴ þ˸ ¶ Ź
ľ ϰ ϴ ŭ ٸ ġ ̹ ߵ ִ ʿϴٰ ߴ.ĵ ٸ Ͽ İ ʴ. 10 ̻ 10 ̴. ġ ɼǵ . ̴ κ ׾ ȭп ̴. ĵ ȯ 80%þ˸ ¶ ó
׾ ȭп ϴ.̹ ̱ ' '(Cell Reports Medicine) ֽȣ ǥƴ.
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